IMPORTANT: The overviews are provided for informational purposes only and should not be used as a substitute for talking with your doctor. Be sure to talk with your healthcare provider for a complete discussion of these conditions as well as the benefits and risks of any treatment options.
Veins play a crucial role in circulating blood back to the heart, but when they don’t work properly, it can lead to problems like varicose veins and chronic venous insufficiency (CVI). CVI occurs when vein valves fail, causing blood pooling, swelling, and skin changes in the legs. Varicose veins often appear with CVI, where veins appear enlarged and twisted.
Deep vein thrombosis (DVT) is the most common cause of chronic venous insufficiency. The blood clot damages the valves and patients with a history of DVT face a higher risk of developing CVI1.
Prolonged
Standing/Sitting
Poor circulation
Age & Family History
Higher risk with aging
Pregnancy & Obesity
Increased venous pressure
History of Deep Vein Thrombosis
Leads to venous damage
Bulging Varicose Veins
Leg Swelling
that worsens throughout the day, heaviness, or aching
Skin Discoloration (brown, red, or purple patches) & thickening
Slow-Healing Venous Ulcers
Chronic Venous Insufficiency (CVI) is often diagnosed with venous duplex ultrasound and staged using the CEAP Classification System, which standardizes assessment based on clinical severity, etiology, anatomy, and pathophysiology (CEAP).
No clinical signs
Telangiectasias or Reticular Veins
No clinical signs
Edema (pitting or non-pitting)3
Pigmentation or Eczema
Lipodermatosclerosis or Atrophie Blanche
Corona Phlebectatica
Healed Venous Ulcer
Active Venous Ulcer4
Recent expert consensus indicates that CEAP C3-C6 CVI patients—characterized by edema—should be managed same as those with lymphedema. This approach acknowledges the interconnectedness of the venous and lymphatic systems, where venous hypertension can lead to lymphatic overload, resulting in combined venous-lymphatic insufficiency, often referred to as phlebolymphedema.
In addition to lifestyle modification and compression therapy, common treatments include prescription medications like blood thinners, and procedural interventions like thrombectomy.
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Dayspring is a FDA-cleared wearable compression treatment indicated for the treatment of lymphedema, phlebolymphedema, venous insufficiency, lipedema, related conditions to chronic edema and supports mobility during treatment5.
An active pipeline development program by Koya that aims to provide a minimally invasive ablation solution that is clinically effective while improving the overall patient experience and accessibility.
