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Research & Publications

Koya Medical is committed to transforming lymphedema and venous care. We are actively developing clinical evidence and partnering with leading clinicians, researchers, and institutions around the world as we continue to bring innovations to this space.

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NILE Study (Interim results)

Randomized prospective multi-center crossover study comparing Dayspring active compression with traditional compression pump In subjects with upper extremity lymphedema (N=52)1


Volume reduction

Responder Rate for Volume Reduction
86% of subjects using Dayspring achieved volume reduction compared to 22% of subjects using a traditional pump



95% treatment adherence was observed for subjects using Dayspring compared to 48% adherence for subjects using a traditional compression pump


Responder Rate for LYMQOL Improvement

LYMQOL improvement was observed in 92% of subjects using Dayspring compared to 38% of subjects using a traditional compression pump


89% Preference

89% of subjects preferred using Dayspring compared to 11% of subjects preferred using traditional compression pump

1Rockson,SG. A Multi-Center RCT Cross-Over Study Evaluating Active Wearable Compression versus Advanced Pneumatic Compression Device for Lymphedema. AVLS 2021 Congress

Dayspring Study

A Non-randomized, Open-Label Study to Evaluate the Safety and Effectiveness of an Active Smart Wearable Compression Technology for Treating Breast Cancer Related Lymphedema, a pilot study  (N=40)2
DOI: 10.1089/lrb.2020.0126

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Preferred dayspring

>90% of study participants preferred study device to existing active compression devices

  • Demonstrated safe and effective use without any adverse events
  • Limb volume was maintained or reduced after 28 days of use
  • Observed 98% adherence over the course of study
LYMQOL Overall Quality of Life
Overall Quality of Life graph
Volume Maintenance
Volume maintenance graph

2 Rockson, SG.; Karaca-Mandic, P.; Skoracki, R.; Hock, K.; Nguyen, M.; Shadduck, K.; Gingerich, P.; Campione, E.; Leifer, A.; Armer, J. Clinical Evaluation of a Novel Wearable Compression Technology in the Treatment of Lymphedema, An Open-Label Controlled Study. Lymphatic Research and Biology 2021, In press.

NIR Study

An imaging study using indocyanine green (ICG) to visualize and evaluate lymphatic response associated with pre and post Dayspring active compression.3

Pre-use arm image
Post use arm image, shows lymph movement
  • Observed lymphatic transport in all subjects post device use
  • Observed subject mobility and treatment limb movement during device use
  • No adverse events reported

3 Wigg J.Near-Infrared (NIR) imaging study of the lymphatic movement in patients with Lymphedem. British Lymphology Society. 2020.

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