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Research & Publications

Koya Medical is committed to transforming venous and lymphatic care. We are actively developing clinical evidence and partnering with leading clinicians, researchers, and institutions around the world as we continue to bring innovations to this space.

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1 Dayspring®

Clinical Evaluation of a Novel Wearable Compression Technology in the Treatment of Lymphedema, an Open-Label Controlled Study

  • Significant improvement in LYMQOL
  • Significant improvement in Individual QoL domains, and limb volume improved with therapy
  • Adherence was 98% over the course of the study

Stanley G Rockson, Pat W. Whitworth, Andrea Cooper, Sarah Kania, Heidi Karnofel, Michelle Nguyen, Kristin Shadduck, Phyllis Gingerich, Jane Armer

Original Article published in Lymphat Res Biol. 2021 https://doi.org/10.1089/lrb.2020.0126

2 Indus

Near-IR Lymphatic Transport Imaging to Evaluate Response to an Ambulatory Smart Wearable Device

  • NIR Imaging demonstrated lymph movement in all subjects with improvement of lymphatic function from use of Dayspring device

Jane Wigg, Elizabeth Campione, Anand Doraiswamy, and Stanley G. Rockson,

Original article presented at: International Lymphodema Framework (ILF) Conference. 2021. Copenhagen, Denmark and Journal of Wound Care. 2022

3 Nile

Safety and Effectiveness of a Novel Non-Pneumatic Active Compression Device for Treating Breast Cancer-Related Lymphedema, a Multi-Center Randomized, Crossover Trial (NILE)

  • Dayspring was found to be more effective than an APCD
  • Significantly greater adherence (95.6% vs. 49.8%), and greater satisfaction (90% vs. 14%)
  • Significantly greater mean reduction in edema volume(64.6% vs. 27.7%) and mean improvements in LYMQOL

Stanley G Rockson, Pat W. Whitworth, Andrea Cooper, Sarah Kania, Heidi Karnofel, Michelle Nguyen, Kristin Shadduck, Phyllis Gingerich, Jane Armer,

Journal of Vascular Surgery. 2022 https://doi.org/10.1016/j.jvsv.2022.06.016

4 Tigris

Near-IR Lymphofluoroscopy for Evaluation of Upper Extremity Lymphoedema using a Non-Pneumatic Active Compression Device

  • ~1.8 years from lymphedema surgery. Unilateral UE lymphedema secondary to breast cancer treatment
  • Daily Dayspring use within 1-month improved QoL and limb volumetrics in patients with long-standing lymphedema not resolved by surgery

Dung Nguyen, Peter Deptula, Halley Darrach, Victoria Posternak, Hui He

Stanford Medicine Symposia and in preparation for publication

5 Tiber

A Non-Randomized, Open-Label Study of the Safety and Effectiveness of a Novel Non-Pneumatic Compression Device (NPCD) for Lower Limb Lymphedema

  • After 3 months of use, subjects had improvement in overall QoL compared with baseline (p<0.05)
  • Limb volume improved (up to 50% reduction in edema) with Dayspring use

Stanley G. Rockson, Pinar Karaca-Mandic, Michelle Nguyen, Kristin Shadduck, Phyllis Gingerich, Elizabeth Campione, and Heather Hettrick

Scientific Reports, Nature. 2022 https://doi.org/10.1038/s41598-022-17225-9

6 Neda

Near-IR Lymphofluoroscopy of Lower Extremity Lymphoedema Treatment with Novel Active Compression

  • NIR Imaging demonstrated lymph movement in all subjects
  • Improvement of lymphatic function from use of Dayspring device

Jane Wigg, Elizabeth Campione, Andy Doraiswamy, and Stanley G. Rockson

Original article in Preparation for Journal of Vascular Surgery. American Venous and Lymphatic Society. 2022

7 Sma

Active Wearable Compression with Shape Memory Actuators for Treating Chronic Edema

  • Comparison and characterization of compression between NPCD and APCD
  • Both NPCD and APCD provide comparable compression pressure ranges
  • NPCD appears to provide more uniform compression than APCD
  • Potential for SMA-based NPCD to address current treatment challenges for chronic edema

John Pamplin, Jarren Baldwin, Julia Rodrick, and Anand Doraiswamy

Shap. Mem. Superelasticity. ASM International. 2022. https://doi.org/10.1007/s40830-022-00379-w

8 Insight

A Novel Handheld Spectroscopy Tool for Detection
of Lymphedema

  • Use of NPCD and a novel diagnostic multimodalspectroscopy tool demonstrates effectiveness of the therapy during a 3-month period across all functions

Jennifer Sibley, Jarren Baldwin, John Pamplin, Julia Rodrick, Charles Liu, Heather Hettrick, and Anand Doraiswamy

Biomedical Materials & Devices (2023). https://link.springer.com/article/10.1007/s44174-023-00070-3

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